The Stairstep lacunae accompanied with multiple closed lacunae, small melanin pigment granulation and contraction furrows at the renal pelvis reaction field - 165'~170' indicate greater tendencies to : - Renal degeneration in the family history. - Poor cellular respiration and increased oxidative stress. - Kreb's Cycle dysfunction. (John Andrews, Iris & Pupillary Signs, 3rd Edition, pg.52)
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