Lacunae at Ciliary & Pupillary Zines - Lx - (gop) - 1

Which location of lacuna is set priority to analyse, a or b ? Which sign can be classified as multidimensional sign, and what MI models can be applied ?

IPB, Pupil Flatness & Local Indentation of the Collarette - Rx - (gop) - 3

Could you analyse and explain the relationship of  above presentation :
a) Local absent of the inner pupillary border tissue 
b) Minor/ Gentle Local Pupil Flatness 
c) Local indentation of the lacuna
These 3 iris signs are located aligned or corresponded to each other at the specific topographical areas !

Rectangular IPB - Rx - (gop) - 2

Identify this IPB sign and zig-zag collarette with polyglandular structure, what are the predisposition weaknesses if combined these two iris signs ?

Gastrointestinal Disturbances Signs - IPB Vs Collarette Structure - Rx - (gop) - 1

Male,66
Digestion, gastric, diarrhea problems.
Please identify which particular iris sign or combination of iris signs indicates the above problems ?