Minor Ray at 30', Medial Nasal Flatness & Indented Lacuna at 90' - Rx - 4

Analyze the combination of iris signs as below:
a) Kreb's Cycle sign at 30 combine with Medial Nasal Flatness.
b) Medial Nasal Flatness combine with Indented Lacuna at 90' 
c) Kreb's Cycle sign at 30' combine with Closed lacuna at 120'
d) CAC sign at 30' combine with Lacuna at ventral section of the collarette - 185'
What are the major genetic deficiencies for the above combination of findings ?