Crypt Vs Lacuna - Rx - ( sunda) - e

Practitioner must set priority to analyse a crypt or lacuna attached on the border of the collarette first and  subsequent a sign on the ciliary zone. The above iris picture showing crypts and lacunae located at different zone ( humoral & ciliary zone), which iris signs is draw you attention to analyse first ? Which one is more significant to an individual in term of genetic deficiency ?