Internal Crypt & Lacuna at Pupillary Zone - Rx

a) Observe the lacuna at 265', 283' with local indentation of the collarette and 280' indicates family inheritance of heart disease. Psycho-emotional possible dealing with grief issues and Time Risk evaluation is recommended. 
b) Internal lacuna & crypt at 270' & 275' embryologically indicate family history of breast problem possible of carcinoma. In cellular level, it indicate blood sugar imbalance associate with malic acid deficiency. This is also can be confirmed by diffuse orange pigment at pupillary zone & pancreas lacunae attached on the external border of the collarette at 290' & 295'.
c) Multiple crypts, internal lacunae and diffuse orange pigment at pupillary zone, they all concentrated at topography areas of ascending colon.