IPB Morphology VS Orange Pigment at 135'

Observe the frontal IPB structure, what type of this IPB which indented (extroflession) toward to the pupil ?,  and identify the potential genetic weakness adhered to this IPB shape. What is the major genetic weakness if combine this morphology tissue together with orange pigment at intestinal zones - 135' 
This is a Globular sign that indicate genetic predisposition to an intestinal dysbiosis, this inherited deficiency enhanced by a solitary pigment located at sigmoid colon reflexive areas !