Crypt at Internal Collarette Border - Classical, Embryological & Cellular Levels - Lx - (cmk)

Commonly, when a practitioner observe a crypt located at descending colon topography areas will suggest the patient is predisposed to encounter a gastrointestinal disturbance tendency, which is fine in classical view. But, in Modern Iridology it can represent multi level of meanings, if a practitioner in view and consider of applying MI models,  it reveal a vital important inheritance DNA weaknesses in embryological & cellular level. What is the difference if the structural sign is internal lacuna, pigment, defect, locaI indentation of the collarette and transversal in response to genetic impact level ?