S-Sign Vs Embryological Sign - Rx - (umah) - 3

 John Andrews stated that as the S sign was related to the function of the hypothalamus and pituitary gland, especially prolactin release, where it is released by the anterior pituitary gland and triggered by the hypothalamus. In this case, if  can we find a hypothalamus sign plus combination with IPB-S sign it genetically enhance the meaning of the prolactinoma deficiency or hyperprolactinaemia (HPRL). Please observe a crypt located at pupillary zone nearest to the pupil edge - 180', this is an embryological sign and indicate a hypothalamus stress that amplify the prolactin insufficiency to this patient !